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KMID : 0380020070220060387
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Korean Journal of Biotechnology and Bioengineering
2007 Volume.22 No. 6 p.387 ~ p.392
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Enhancement of DNA Microarray Hybridization using Microfluidic Biochip
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Abstract
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Recently, microfluidic biochips for DNA microarray are providing a number of advantages such as, reduction in reagent volume, high-throughput parallel sample screening, automation of processing, and reduction in hybridization time. Particularly, the enhancement of target probe hybridization by decrease of hybridization time is an important aspect highlighting the advantage of microfluidic DNA microarray platform. Fundamental issues to overcome extremely slow diffusion-limited hybridization are based on physical, electrical or fluidic dynamical mixing technology. So far, there have been some reports on the enhancement of the hybridization with the microfluidic platforms. In this review, their principle, performance, and outreaching of the technology are overviewed and discussed for the implementation into many bio-applications.
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KEYWORD
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Microfluidic, biochip, DNA microarray, hybridization, chaotic mixer
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